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How The Pathology Of Parkinson's Disease Spreads
Accumulation of the synaptic protein alpha-synuclein, resulting in the formation of aggregates called Lewy bodies in the brain, is a hallmark of Parkinson"s and other related neurodegenerative diseases. This pathology appears to spread throughout the brain as the disease progresses. Now, researchers at the University of California, San Diego School of Medicine and Konkuk University in Seoul, South Korea, have described how this mechanism works. Their findings - the first to show neuron-to-neuron transmission of alpha-synuclein - will appear in the Proceedings of the National Academy of Sciences (PNAS) on July 29.
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Senate GOP Escalates Criticism Of Supreme Court Nominee Sotomayor In Speeches
Senate Republicans on Tuesday in the first in a series of floor addresses launched more strongly worded criticism of Supreme Court nominee Judge Sonia Sotomayor"s judicial record and previous speeches, Politico reports. Although the floor speeches are not likely to undermine the Democratic majority"s support for Sotomayor or block her confirmation, they indicate a shift in strategy for the GOP as it tries to generate more opposition to the nomination, according to Politico. As senators approach the weeklong July 4 recess, Republicans are attempting to show that they have "no intention of lying down in the face of what appears to be an increasingly inevitable confirmation," Politico reports. Senate Minority Leader Mitch McConnell (R-Ky.), Senate Judiciary Committee ranking Republican Jeff Sessions (Ala.) and Sen. John Cornyn (R-Texas) used their time on the Senate floor to attempt to portray Sotomayor as a "judicial activist" and to attack President Obama"s previous statements that he would like to appoint a judge who displays "empathy" (Isenstadt, Politico, 6/24). Republicans also reiterated they will attempt to delay Sotomayor"s confirmation hearing, scheduled to begin July 13, if they do not feel they have enough time to review her judicial record, Roll Call reports. They also questioned Sotomayor"s involvement with the civil rights group LatinoJustice PRLDEF, which they labeled "far left," taking up a line of criticism that other conservatives have pushed. Sotomayor served as a board member for the group from 1980 to 1992. Democrats and White House officials are aggressively defending Sotomayor"s record, arguing that her lengthy judicial career supersedes any public statements or speeches she made in the past, according to Roll Call. Both said that their strategy is to avoid a point-counterpoint argument with Republicans. A White House official said there is "no reason to speculate on her record," which includes more than 3,000 panel decisions. Senate Judiciary Committee Chair Patrick Leahy (D-Vt.) said that he has been "struck by her extraordinary career and how she"s excelled at everything she"s done." Leahy said that he is not convinced that Republicans need more time, noting that the Senate is using the same confirmation timetable as it used for Chief Justice John Roberts. Although Leahy said that he might be willing to discuss a schedule change if Republicans agreed not to filibuster or delay the nomination, he added that Republicans have not suggested such a deal at this point (Stanton, Roll Call, 6/24).
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Impax Receives FDA Approval For Generic Precose(R) Tablets, 25 Mg, 50 Mg And 100 Mg
Impax Laboratories, Inc. (NASDAQ: IPXL) confirmed that the U.S. Food and Drug Administration (FDA) has granted approval of the Company"s Abbreviated New Drug Application (ANDA) for generic versions of Precose® Tablets (acarbose), 25 mg, 50 mg and 100 mg strengths. Precose®, a Bayer HealthCare Pharmaceuticals product, is used in the management of type two diabetes mellitus.
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Widespead And On The Increase - Vitamin D Deficiency

A new report issued by the International Osteoporosis Foundation (IOF) and published in the scientific journal Osteoporosis International1, shows that populations across the globe are suffering from the impact of low levels of vitamin D. The problem is widespread and on the increase, with potentially severe repercussions for overall health and fracture rates. Compiled by IOF"s expert working group on nutrition, the report reviews the scope and causes of low vitamin D levels in six regions: Asia, Europe, Latin America, Middle East and Africa, North America and Oceania. Regional reports are available on the IOF website Vitamin D is mainly produced in the skin upon exposure to sunlight, and, to a lesser extent, is derived from nutritional s. It plays an important role, through its influence on calcium levels, in the maintenance of organ systems, and is needed for normal bone mineralization and growth. Suboptimal levels of vitamin D may lead to increased risk of osteoporosis and hip fracture and, in severe cases, to the development of rickets, a softening of bones in children that can lead to skeletal fractures and deformity. Although there is ongoing debate as to what constitutes the optimal level of vitamin D, the report shows that regardless of whether it is defined at 50nmol/L or 75nmol/L, vitamin D status is seriously inadequate in large proportions of the population across the globe. The main risk factors for low vitamin D levels include older age, female sex, lower latitudes, winter season, darker skin pigmentation, less sunlight exposure, dietary habits, and the absence of vitamin D fortification in common foods. Further factors include the increase in urbanization, where people tend to live and work indoors, as well as cultural practices that tend towards sun avoidance and the wearing of traditional clothing that covers the skin. The severity of the problem in Middle East and South Asia arises from the combination of several of these risk factors. These findings suggest that prevention strategies must be initiated at the national level - especially given the increasing ageing of populations in many regions of the world. National plans of action should encourage safe, limited exposure to sunlight and improved dietary intake of vitamin D, whilst considering fortification of foods as well. Notes: 1. A. Mithal, D.A. Wahl, J-P. Bonjour et al. on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group. Global vitamin D status and determinants of hypovitaminosis D (2009) Osteoporosis International, in press. 2. Regional reports for Asia, Europe, Latin America, Middle East and Africa, North America and Oceania may be downloaded free of charge from the IOF website. L. Misteli International Osteoporosis Foundation


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