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Lower College GPA And Evening Chronotype In High School Students Linked
According to a research abstract at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, students who consider themselves to be evening types (that is someone who feels more alert and does their best work later in the day) have poorer sleep hygiene scores than morning and intermediate types. Sleep hygiene is the group of behaviors linked to good sleep and alertness. Examples include having a regular bedtime routine, a regular wake time, a regular bed time, and sleeping in a comfortable bed. The researchers found that this poor sleep hygiene was related to poorer academic performance and a decline in grade point average (GPA) during the transition from high school to college.
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Genetically Engineered Mice Yield Clues To 'Knocking Out' Cancer
Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer. That"s the conclusion of a recent study* in DNA Repair by researchers at the National Institute of Standards and Technology (NIST), Oregon Health and Science University (OHSU) and the New York University School of Medicine (NYUSM).
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Researchers Find How A Common Genetic Mutation Makes Cancer Radiation Resistant
Many cancerous tumors possess a genetic mutation that disables a tumor suppressor called PTEN. Now researchers at Washington University School of Medicine in St. Louis have shown why inactivation of PTEN allows tumors to resist radiation therapy.
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Risk Factors For Sleep Disordered Breathing In Children: Waist Size And Body Mass Index

A study in the June 1 issue of the journal SLEEP found that waist circumference and body mass index (BMI) are consistent, independent risk factors for all severity levels of sleep disordered breathing (SDB) in children, suggesting that as with adult SDB, metabolic factors are important risk factors for childhood SDB. Results indicate that BMI and waist circumference, but not neck circumference, were significant and strong predictors of SDB at all severity levels - primary snoring, mild SDB and moderate SDB. Nasal anatomic factors such as chronic sinusitis, rhinitis and nasal drain were significant predictors of mild SDB; minority status was associated with primary snoring and mild SDB. Tonsil size, assessed by visual inspection, was not a significant risk factor for any level of SDB. Overall, 1.2 percent of children had moderate SDB (an apnea/hypopnea index of five or more breathing pauses per hour of sleep), 25 percent had mild SDB (AHI of at least one but less than five) and 15.5 percent had primary snoring. According to principal investigator Edward O. Bixler, PhD, of Penn State University College of Medicine in Hershey, Penn., it is often assumed that the primary mechanism of SDB in children is the presence of large tonsils or adenoids. The study suggests, however, that the causes of SDB in children are more complex, that there may be a systemic influence of obesity, and that adenotonsillectomy may not always be the most effective, first-line treatment. "Risk factors for SDB in children are complex and include metabolic, inflammatory and anatomic factors," said Bixler. "Because SDB in children is not just the outcome of anatomical abnormalities, treatment strategies should consider alternative options, such as weight loss and correction of nasal problems." The American Academy of Sleep Medicine reports that snoring is one warning sign for obstructive sleep apnea, a common form of SDB that occurs when soft tissue in the back of the throat collapses and blocks the airway during sleep. Snoring that is related to sleep apnea tends to be loud and may include obvious pauses in breathing and gasps for breath. Parents often notice that the child seems to be working hard to breathe during sleep. The study gathered data from 700 children between the ages of 5 and 12 years who were randomly selected from 18 public elementary schools in Dauphin County, Penn. Fifty-two percent were female, and 23.8 percent of the children were either Black or Hispanic. Each child was evaluated by a physical exam and monitored for nine hours during one night of polysomnography in a sleep laboratory. The overall average AHI was 0.8 breathing pauses per hour of sleep, with a maximum value of 24.6. The prevalence of moderate SDB was higher in older children; two percent of children between the ages of 9 and 12 years had moderate SDB, compared with only 0.2 percent of children between 5 and 8 years of age. The study: "Sleep Disordered Breathing in Children in a General Population Sample: prevalence and Risk Factors" Kelly Wagner American Academy of Sleep Medicine


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