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What Is A Heart Attack? What Causes A Heart Attack?
If the heart muscle does not have enough blood (and consequently oxygen) it dies and a heart attack occurs. Another name for a heart attack is myocardial infarction, cardiac infarction and coronary thrombosis. According to Medilexicon"s medical dictionary, a heart attack is "infarction of a segment of heart muscle, usually due to occlusion of a coronary artery". (Infarction = the process whereby an area of dead tissue is caused by a loss of blood supply).
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International Symposium On Atherosclerosis Highlights Latest Treatment Advancements
Atherosclerosis, or hardening of the arteries with plaque buildup, is the underlying cause of heart disease and stroke, which together account for more than half of all death and disability in developed nations. The world"s largest forum for new research on the topic, the International Symposium on Atherosclerosis (ISA), will hold its 15th triennial meeting at the John B. Hynes Veterans Memorial Convention Center in Boston, June 14 to 18.
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HHS To Propose Removal Of HIV From List Preventing Foreigners U.S. Entry
HHS this week will issue proposed regulations to remove HIV from the list of "communicable diseases of public health significance," effectively lifting the ban on HIV-positive foreign residents from entering the country, Newsday reports (Reddy, 6/29). Last year, then-President George W. Bush signed into law a provision to remove HIV from the HHS list, the Washington Post"s blog, "44," reports. The proposed rule has to be published in the Federal Register, and then undergo a 45-day comment period before becoming finalized (Hsu, 6/29).
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Orexo Announces Positive Phase III Results For KW-2246 In Japan

Orexo"s (STO:ORX) partner in Japan, Kyowa Hakko Kirin, has obtained positive phase III results in Japan for KW-2246, which is approved for the treatment of breakthrough pain in cancer patients and marketed under the brand AbstralTM in Europe. Kyowa Hakko Kirin will now proceed with preparations for a new-drug application for KW-2246 in Japan for use in continuous pain management of acute cancer pain (breakthrough pain). Orexo announces that Kyowa Hakko Kirin, Orexo"s partner in Japan, today confirms that it has obtained positive clinical phase III results for KW-2246 in Japan. The clinical study results revealed a statistically significant difference between KW-2246 and the placebo, and clinical effectiveness was confirmed. In addition, with regard to safety, no unacceptable side effects were found during the clinical study period. Kyowa Hakko Kirin will now proceed with the preparations for a new-drug application for KW-2246 in Japan. According to the market research institute Datamonitor, the Japanese market for opioids is one of the largest markets in the world (Datamonitor 2008, Commercial and Pipeline Insight: Opioids). Torbjç¶rn Bjerke, President and CEO of Orexo, comments: "The positive phase III results in Japan are an important milestone for our successful collaboration with Kyowa Hakko Kirin. This marks another important step in the international development of AbstralTM and strengthening Orexo in the process of becoming a profitable pharmaceutical company". Trial design The clinical study was conducted using a crossover design involving a double-blind placebo-controlled trial, targeting patients to whom an opioid analgesic was administered at fixed intervals for intermediate to severe cancer pain and who use a morphine preparation for breakthrough pain, and a non-blind controlled trial with a morphine preparation. About Abstral Abstral is a fast-dissolving tablet for sub-lingual administration of fentanyl, intended for the management of breakthrough cancer pain in patients who are already receiving opioid analgesics. It is based on Orexo"s unique and patented sublingual tablet technology in which a rapidly dissolving tablet is placed under the tongue and the active substance is absorbed by the mucous membrane. Currently Abstral is sold in Sweden, UK and Germany and is ready for launch in France. In Sweden, Abstral is sold through Orexo"s and ProStrakan"s joint venture, ProStrakan AB. The product is being prepared for registration in Japan and in the US the clinical phase III is finalized. License agreements have been signed with Kyowa Hakko Kirin for Japan and with ProStrakan for EU and the US. Distribution agreements regarding Abstral for Russia and the CIS, Bulgaria and Rumania have been signed with Gedeon Richter. A distribution agreement has been signed with Hospira for the Southeast Asian market. For the Chinese market, Orexo has signed a distribution agreement with NovaMed, and for the Israeli market Orexo has signed a distribution agreement with Neopharm. About Kyowa Hakko Kirin Kyowa Hakko Kirin Co., Ltd. is engaged in the manufacturing and marketing of medical products and pharmaceuticals. As the parent company of the Kyowa Hakko Kirin Group, it manages the business activities in the Bio-Chemicals and Chemicals segments with the Pharmaceuticals segment as its core business. More information can be found at http://www.kyowa-kirin.co.jp/english/index.html. Orexo


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