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Individual Bacterial Cells Are Capable Of Quorum Sensing When Confined In Small Volumes
Infections of wounds, pneumonia, etc. in hospitals in particular are often caused by bacteria called Pseudomonas aeruginosa. Once they reach a certain density, colonies of Pseudomonas aeruginosa produce virulence factors and can enter into a slimy state, a biofilm, which prevents antibiotics from penetrating. The process of quorum sensing, which cells use to "sense" cell density, is triggered when the concentration of certain signaling compounds generated by the bacteria reaches a threshold level. A team working with Rustem F. Ismagilov at the University of Chicago has now demonstrated that the absolute number of cells is irrelevant; only the number of bacteria in a given volume plays a role. As the researchers report in the journal Angewandte Chemie, they were even able to trigger quorum-sensing processes in single cells when these were confined in extremely small volumes.
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New Informa Healthcare Web Site Now Live - Site Features More Than 180 Peer-Reviewed Journals

Informa Healthcare - one of the world"s leading medical and scientific publishers- has announced that the new interactive http://www.informahealthcare.com site is now live and delivers online content from more than 180 peer-reviewed journals. The site combines all the Informa Healthcare journal titleslisted on InformaWorld.com and InformaPharmaScience.com to help simplify the customer experience. The new site utilizes the online content management and delivery system provided by Atypon Systems, Inc. - an e-publishing solutions supplier for a number of leading information providers including JSTOR, New England Journal of Medicine and the American Chemical Society. The Atypon system enables Informa Healthcare to integrate a comprehensive archive service - dating back to 1918 - giving pharmaceutical, medical and healthcare professionals one central, high-quality of information. "The new site will help researchers, authors and librarians connect user behavior through commonly read articles," said Phil Garner, Publishing Director at Informa Healthcare. "Our goal is to offer a robust selection of specialty content to promote information exchange and further professional research or development." The new platform offers the option of online trials, advanced searching, alerting, and single article purchases. The site also provides COUNTER-compliant reports and statistics to help subscribers analyze usage. "We are delighted to be able to partner with Informa Healthcare and provide a cost-effective, interactive platform that offers great functionality and navigation options," said Chris Beckett, Vice President of Sales and Marketing, Atypon Systems. "We have worked closely with Informa HealthCare to deliver a site that will grow their revenues and better engage their user community." There will be a dual-hosting period with the InformaWorld platform, which currently hosts the medical content, through 2009 allowing for a gradual migration. Informa Healthcare will set up customer accounts in August and will notify subscribers of the change to ensure a seamless transition to the new site. Customers with journals on InformaPharmaScience.com will be automatically re-directed. "We want to make the transition as easy and productive as possible for our customers," said Phil. "We encourage healthcare, academic and corporate professionals to review the new site and send us feedback." To review a list of journal titles on the new site or for more information, visit http://www.informahealthcare.com. Informa Healthcare


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