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MicroRNAs Help Control HIV Life Cycle
Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, miR29 plays a key role in controlling the HIV life cycle. The study suggests that HIV may have co-opted this cellular defense mechanism to help the virus hide from the immune system and antiviral drugs. The research was published today in the journal Molecular Cell.
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ZymoGenetics Reports Encouraging Preliminary Results From Phase 2 Study Of IL-21 In Metastatic Melanoma Conducted By NCIC
ZymoGenetics, Inc. (NASDAQ:ZGEN) announced that Interleukin 21 (IL-21) demonstrated an impressive overall response rate in the treatment of metastatic melanoma. In interim Phase 2 results from 24 patients, 29 percent showed a partial response, with an additional 33 percent of patients showing stable disease in this difficult to treat disease.
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In Pediatric Patients Sleep Disorders Are Largely Underdiagnosed
Primary care pediatricians may be under-diagnosing sleep disorders in children and teens, according to a research abstract presented on June 8 at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.
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Lawmakers, Spouses Ties To Health Industry Shape Views

Nearly 50 lawmakers in Congress have spouses who work in the health care industry and that may be influencing their thinking on health reform, CQ Politics reports. "Financial disclosure forms made public in mid-June showed that at least 39 members were tied to the industry by their spouses in 2008. In addition, 13 full-voting House members are medical doctors. Six senators reported that their spouses earned income from health industry jobs. An additional two, Republicans Tom Coburn of Oklahoma and John Barrasso of Wyoming, are physicians. The influence and connections that result from this little-examined reality of Washington life rarely violate ethics rules or laws. But the experiences can make a significant difference in how members view health care overhaul proposals." Sen. Chris Dodd"s wife also works in the medical industry, and "to ensure no ethical questions arise" from her deep involvement with industry stakeholders, "Dodd has brought in an ethics adviser to guide him. "Jackie Clegg Dodd"s career is her own, absolutely independent of Sen. Dodd, as it was when they married 10 years ago," said Dodd spokesman Bryan DeAngelis" (Epstein, 6/23). In the meantime, Nancy-Ann DeParle, President Obama"s White House health care czar, earned at least $2.3 million working for health care companies in 2008 and early 2009, reported The Associated Press: "DeParle disclosed compensation for her service on the boards of directors of Cerner Corp., Boston Scientific Corp., and Medco Health Solutions Inc. She also served as managing director of CCMP Capital last year through this February, and on the DaVita Inc. board of directors from January through July 2008" (Theimer, 6/23). This information was reprinted from kaiserhealthnews.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives and sign up for email delivery at kaiserhealthnews.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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