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Landmark Five-Year African Study Indicates That HIV Therapy May Be Given Safely In Re-Limited Settings Without Routine Laboratory Monitoring
Gilead Sciences, Inc. (Nasdaq:GILD) highlighted results from a study known as DART (Development of Anti-Retroviral Treatment in Africa), which evaluated the need for routine laboratory monitoring in adults taking antiretroviral therapy in Africa. The DART trial was an open-label, randomized study comparing clinical and laboratory monitoring to clinical monitoring alone for efficacy and toxicity. In this study, 74 percent of patients were on a treatment regimen containing Viread® (tenofovir disoproxil fumarate). At baseline, more than 50 percent of patients had reduced renal function. The results indicated that Viread was well tolerated and that the incidence of renal adverse events was low. DART researchers concluded that renal function test results were similar in both arms of the trial for up to five years, suggesting that routine monitoring of Viread may not be necessary in re-limited settings when using the product as part of a first-line HIV treatment regimen. The results of the study were presented today at the 5th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2009) in Cape Town, South Africa.
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Ensuring Seniors Are Safe And Secure During Emergencies

Planning for emergencies must take into account the growing numbers of frail elderly people who will by virtue of shifting demographics be involved in any natural or manmade disaster, according to US researchers writing in the International Journal of Emergency Management. As the world"s population grows and more individuals are living into their 70s, 80s, and 90s, those charged with managing people, res, and medical care during and after an emergency, whether heat wave, flood, fire, earthquake, or other disaster, will face increasing challenges in addressing the needs of frail elderly people at such times. Susan Smith and colleagues at the University of Tennessee Safety Center in Knoxville, working with Mary Jane Tremethick at Northern Michigan University, expose the factors affecting the frail elderly during and after an emergency and propose strategies to minimize the impact on this vulnerable group of people. In 2008, the World Health Organization (WHO) stated that it should be a primary goal of emergency management teams to support older people in an emergency, to minimize harm, and to help them maintain the highest possible level of health and functional capacity and to aid them in recovering from a disaster as quickly as possible. Smith and her colleagues suggest that, in the light of the WHO"s statement, rapid response to a crisis must extend beyond the traditional emergency response personnel. In short "age-responsive" actions must be identified and integrated into risk assessments and disaster response plans. They cite recent examples of heat waves in France, Greece, and the USA, and the US 2005 hurricane season, where such an approach may have reduced considerably the number of deaths among the elderly. The first point that they address is how to define someone as frail elderly and so more at risk than a healthy younger person. "The term "frail elderly" refers to adults over the age of 60 suffering from the effects of physical, mental, and sensory deterioration due to age and chronic diseases," the team explains. The frail elderly may therefore be severely affected in their ability to recognize and respond to a disaster. The definition must also encompass the fact that many frail elderly people economically poor or socially isolated and so at even greater risk during and after an emergency situation. Fundamentally, factors such as declining health and increased chronic diseases, limitations in sight, hearing and mobility, limited access to healthcare res, low economic status, and restricted social networks, all shift the risk a person faces in an emergency. "The unique needs of the frail elderly were cited for disaster warnings, evacuation plans, and shelter locations," Smith and colleagues say, "Through collaboration with community organizations and members, emergency professionals, can exercise leadership to improve disaster response for the vulnerable population of the frail elderly," the teams says. They suggest that future research aimed at documenting the most successful organizational methods of providing a community, country and global response and recovery with respect to the frail elderly should be carried out. "Disaster planning and response: considering the needs of the frail elderly" in Int. J. Emergency Management, 2009, 6, 1-13 Susan Smith Inderscience Publishers


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