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Popular Articles

Survival Of Patients With Idiopathic Pulmonary Fibrosis (IPF) Does Not Improve With Interferon Gamma-1b Treatment
An article published Online First and in an upcoming edition of The Lancet reports the findings of the INSPIRE trial on treatment of idiopathic pulmonary fibrosis (IPF) with interferon gamma-1b (Ifn-g1b). It is written by Professor Talmadge E King Jr, of the University of California, San Francisco (UCSF), USA and his team. Results show no improvement in survival compared with placebo. There is no effective treatment for IPF which is a fatal disease.
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What Are Kidney Stones? What Causes Kidney Stones?
Kidney stones, usually comprised of a compound called calcium oxalate, are the result of a build-up of dissolved minerals on the inner lining of the kidneys. These deposits can grow to the size of a golf ball while maintaining a sharp, crystalline structure. They may be small and pass unnoticed out of the urinary tract, but they may also cause extreme pain upon exiting. Kidney stones that remain inside the body can lead to many conditions, including severe pain and ureter (the tube connecting the kidney and bladder) blockage that obstructs the path urine uses to leave the body.
News of the day
Obama Has Larger Pool Of Female Judges To Select From For Supreme Court Nominee
In selecting a Supreme Court nominee, President Obama will have a more diverse pool of judges to choose from than his predecessors did, largely because the number of women on the federal bench has increased dramatically over the past two decades, the AP/Kansas City Star reports. Just two of the 110 justices that have served on the Supreme Court are women: former Justice Sandra Day O"Connor and current Justice Ruth Bader Ginsburg. Most of the candidates Obama is considering are women.According to the AP/Star, there are 212 full-time female judges serving in the federal courts, meaning that women make up more than one quarter of the federal judiciary. In contrast, there were about 40 female federal judges during the Reagan administration. In addition, women make up at least 40% of the judges on 22 of the 53 state supreme courts, another likely for nominees. The AP/Star reports that the increase in the number of female judges reflects the rise in the number of practicing female lawyers; women currently account for about one-third of lawyers and nearly half of all law school graduates. Marcia Greenberger, co-president of the National Women"s Law Center, said, "I wouldn"t say the doors have swung open as fully as we would like." She added, "Nonetheless, there are superb women in the judiciary, academia and private practice."The AP/Star also reports that Obama might seek to increase racial diversity on the Supreme Court, as only two of the 110 justices have been black men: current Justice Clarence Thomas and former Justice Thurgood Marshall. There has never been a Hispanic, Asian-American or American Indian justice (Sherman, AP/Kansas City Star, 5/20).
Diagnostics

$3.7M NIH Grant To Study Autonomic Nervous System Link To Painful Bladder Syndrome, Received By Case Western Reserve University

Case Western Reserve University School of Medicine has received a $3.7 million grant from the National Institutes of Health to determine if painful bladder syndrome may be caused by abnormalities in the autonomic nervous system rather than in the bladder itself. Principal investigator of the project is Thomas Chelimsky, M.D., professor of neurology at the Case Western Reserve University School of Medicine, and director of autonomic disorders at University Hospitals Case Medical Center and the University Hospitals Neurological Institute. Sites participating in the five-year study are University Hospitals (Drs. Chelimsky and Jeffrey Janata), The Ohio State University (Dr. Tony Buffington), Cleveland Clinic (D. Ray Rackley), and Summa Health System (Dr. Brad Fenton). Interstitial cystitis/painful bladder syndrome (IC/PBS) causes severe bladder pain and extensive disability in a large group of young women in the prime of their productive lives. The cause of IC/PBS remains unknown, and there is no cure. Symptoms may vary, but women with it may experience mild discomfort, pressure, tenderness, or intense pain in the bladder and pelvic area. Symptoms may include an urgent need to urinate, a frequent need to urinate, or a combination of these symptoms. "We have found that other autonomic disorders often occur in both the patients themselves and in the family members of patients with IC/PBS. We therefore propose to determine whether the main abnormality in IC/PBS actually lies in the autonomic nervous system rather than the bladder itself," said Dr. Chelimsky. The autonomic nervous system is in charge of all internal organs such as the bowel, the bladder, blood pressure and heart rate. For obvious reasons, diseases that affect the autonomic nervous system are sometimes misdiagnosed as diseases of the internal organ itself. "IC/PBS may actually be a member of a larger family of disorders that share a family predisposition for abnormal central autonomic and sensory responses to stress, pain or threat, usually first appearing following a traumatic event such as infection and injury," continued Dr. Chelimsky. In the new study, the researchers will do this through measurements of autonomic function and sensation in patients who have IC/PBS, both at rest, and under controlled psychological stress. These research subjects will be compared with healthy patients, and patients with chronic pelvic pain without IC/PBS. "We"ve designed the study to lead to a better understanding of the causes for this condition and to lead to possible suggestions for new treatments," said Dr. Chelimsky. Christina DeAngelis Case Western Reserve University


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